Ultrasound Assessment of Joint Health in Patients With Mild Hemophilia (Factor Levels 5-40%)

Currently, few recommendations exist for patients with mild hemophilia, who represent approximately 60% of the hemophilia population. This study aims to provide objective data on joint health in these patients, which are currently limited compared to those with moderate or severe hemophilia. The use of joint ultrasound in mild hemophilia could allow early, asymptomatic detection of joint damage, support tailored management including patient education, and ultimately improve quality of life. The study will also explore the correlation between coagulation factor levels (FVIII or FIX) and other indicators of joint health in France.

NCT Number	NCT07719647
Lead Sponsor	Assistance Publique - Hôpitaux de Paris Collaborators: URC-CIC Paris Descartes Necker Cochin, Swedish Orphan Biovitrum
Conditions	Mild Hemophilia
Enrollment	150 participants
Start Date	2026-09
Primary Completion	2027-09 (estimated)
Study Completion	2027-09 (estimated)
Updated on ClinicalTrials.gov	2026-07-22