A Clinical Trial to Compare the Photoprotective Effects of Cucumber Seed Extract vs Placebo in Filipino Adults by Measurement of Minimal Erythema Dose

A monocentric, randomized, split-body, double-blind, controlled trial was conducted on 29 Filipino adults with Fitzpatrick skin types III-V. Topical 2% and 4% cucumber seed extract gels and placebo were applied to randomized sites on the lower back, followed by incremental narrow-band UVB exposure. MED was assessed 24 hours post-exposure. Repeated measures ANOVA and paired t-tests were used for statistical analysis.

NCT Number	NCT07719413
Lead Sponsor	DOH - Tondo Medical Center
Conditions	Healthy Human Volunteers With Fitzpatrick Skin Type III-V, Sunburn, Erythema
Enrollment	29 participants
Start Date	2025-01-27
Primary Completion	2025-02-26 (estimated)
Study Completion	2025-02-28 (estimated)
Updated on ClinicalTrials.gov	2026-07-31