Study of Disulfiram to Reduce Myeloid Immunosuppression and Steroid Dependence in Resectable High Grade Glioma

This research study is for participants with glioblastoma. It can cause a tumor immunosuppression which helps myeloid cells that can stop T-cell function. Disulfiram is a drug that has been used in treating other disorders, but this study will examine if disulfiram can help make the tumor environment less immunosuppressive and reduce brain swelling when taken before surgery.

NCT Number	NCT07719127
Lead Sponsor	Case Comprehensive Cancer Center
Conditions	Brain (Nervous System) Cancers
Enrollment	20 participants
Start Date	2026-10
Primary Completion	2027-12-17 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-22