Observational Approach Versus Surgical Intervention for Stones

The aims of the Observational Approach versus Surgical Intervention for Asymptomatic Stone (OASIS) trial are: 1) to determine whether observation compared to upfront surgery results in less healthcare-related life disruption due to kidney stones among children and adults with asymptomatic kidney stones; 2) to identify the groups benefiting the most from each strategy; and 3) to determine the preferences and values informing the choice between observation and upfront surgery.

NCT Number	NCT07718802
Lead Sponsor	Children's Hospital of Philadelphia Collaborators: Patient-Centered Outcomes Research Institute
Conditions	Nephrolithiasis, Kidney Stone
Enrollment	1,658 participants
Start Date	2026-08-01
Primary Completion	2031-05-31 (estimated)
Study Completion	2032-10-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-22