Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery

Acute kidney injury (AKI) is common after cardiac surgery, yet effective protective strategies remain limited. L-arginine is the substrate for endogenous nitric oxide (NO) synthesis and may improve renal perfusion and endothelial function. investigators emulated a target trial to evaluate whether early perioperative L-arginine was associated with a lower risk of AKI after cardiac surgery.

NCT Number	NCT07718373
Lead Sponsor	Xijing Hospital
Conditions	Acute Kidney Injury
Enrollment	5,000 participants
Start Date	2026-07-20
Primary Completion	2026-08-20 (estimated)
Study Completion	2026-08-20 (estimated)
Updated on ClinicalTrials.gov	2026-08-10