Adequacy of Haemodiafiltration: Middle Molecules Clearance, Patients Reported Outcomes and Sodium Balance

The goal of this observational study is to understand the differences in terms of middle molecules clearance and patient outcomes in High (\>23Litres (L)) vs Low (\<23 L) convection volume (CV) Hemodiafiltration (HDF) and to understand the effect of dialysate fluid sodium concentration (137 vs 140 mmol/L) on overhydration volume in patients on HD and HDF.

NCT Number	NCT07717255
Lead Sponsor	East and North Hertfordshire NHS Trust
Conditions	Haemodiafiltration, Haemodialysis, Patient Reported Outcome Measurements, Nutrition, Malnutrition (Calorie), Fluid Balance Outcomes
Enrollment	300 participants
Start Date	2025-01-09
Primary Completion	2030-11-01 (estimated)
Study Completion	2030-11-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-21