Estimation of Control Before and After Treatment of a Depressive Episode With Serotonin Reuptake Inhibitors

The goal of this observational study is to better understand cognitive and affective processes involved in depression, in particular how individuals estimate their perception of control over events in their environment, as well as related processes such as memory and decision-making. The study also aims to investigate how these processes are affected by antidepressant treatment and how depressive symptoms evolve over time, as well as whether specific peripheral markers (including hormones) are associated with treatment effects.

NCT Number	NCT07716982
Lead Sponsor	Hôpital le Vinatier Collaborators: INSERM U1028
Conditions	Depression Disorder
Enrollment	124 participants
Start Date	2026-09
Primary Completion	2029-12 (estimated)
Study Completion	2029-12 (estimated)
Updated on ClinicalTrials.gov	2026-07-21