Recontrast and Renal Outcomes in Patients With Pre-Existing Renal Dysfunction

Aim of study: The renal impact of repeated iodinated contrast exposure in critically ill patients with pre-existing renal impairment Methods: A prospective observational cohort study included 112 critically ill patients admitted to the intensive care units of Cairo University hospitals with baseline estimated glomerular filtration rate (eGFR) \<90 mL/min/1.73 m² who underwent one or two intravascular iodinated contrast administrations. Hemodynamically unstable patients were excluded. Patients were systematically followed to evaluate both short- and long-term renal outcomes. Serum creatinine, eGFR, urine output, contrast-associated acute kidney injury (CA-AKI), chronic kidney disease (CKD) progression and dialysis requirement were assessed after each exposure and during 6 months follow-up. Logistic regression analysis was performed.

NCT Number	NCT07713524
Lead Sponsor	Cairo University
Conditions	Kidney Diseases
Enrollment	112 participants
Start Date	2024-03-01
Primary Completion	2025-11-30 (estimated)
Study Completion	2026-02-28 (estimated)
Updated on ClinicalTrials.gov	2026-07-21