A Cohort Study on the Integrated Management of Chronic Kidney Disease

The study will leverage the established multi-stage cohort resources at Huashan Hospital, covering the entire spectrum from early-stage CKD to dialysis, including a comorbidity real-world database, a prospective CKD patient cohort, and a maintenance hemodialysis patient real-world cohort. It will also collaborate with the Shanghai Fifth People's Hospital (community-based CKD cohort, n\>2,000) and the Jing'an District Central Hospital (end-stage renal disease cohort, n\>400) as external validation platforms. Using epidemiological and big data-driven approaches, the study aims to elucidate the mechanisms underlying disease progression and complications, construct intelligent intervention models, and validate their performance in the external cohorts, ultimately facilitating the optimization and broader application of comprehensive CKD management strategies.

NCT Number	NCT07712341
Lead Sponsor	Huashan Hospital Collaborators: Jingan District Central Hospital of Shanghai (Jingan Branch of Huashan Hospital Affiliated to Fudan University), Fudan University Affiliated Shanghai Fifth People's Hospital Hospital
Conditions	Chronic Kidney Disease, Stage 5, Chronic Kidney Disease, Stage 4, Chronic Kidney Disease, Stage 3
Enrollment	4,029 participants
Start Date	2026-09-01
Primary Completion	2028-08-30 (estimated)
Study Completion	2028-08-30 (estimated)
Updated on ClinicalTrials.gov	2026-07-17