I-CAN Uganda Effectiveness Trial

This is a cluster-randomized controlled trial to determine the effectiveness of the community-based "I-CAN" intervention to improve agency in contraceptive decision-making and use in rural Uganda. Lay women will be trained to serve as peer mentors to other women of reproductive age in the community, using their own lived experience to provide support and information about contraceptive choices. Villages will be randomized to either receive the intervention or not. A household survey will be conducted at baseline before implementation activities begin and 24 months later. Interviews will also be conducted with mentors, participants, male partners of participants and other stakeholders. Researchers will compare preference-aligned contraceptive use (primary outcome), contraceptive agency, contraceptive method satisfaction, preference-aligned fertility management, and use of self-injectable contraception in villages with and without the intervention to determine effectiveness.

NCT Number	NCT07711717
Lead Sponsor	University of California, San Francisco Collaborators: Makerere University, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Baitambogwe Community Healthcare Initiative (BACHI), AIDS Information Centre - Uganda (AIC)
Conditions	Contraception
Enrollment	1,560 participants
Start Date	2026-10-13
Primary Completion	2028-12-31 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-23