Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity?

So far, treatment with semaglutide (Wegovy) for therapy of obesity demonstrates substantial effects. However, most patients do not desire life-long pharmaceutical therapy or discontinue this treatment regime. This is accompanied by rapid weight regain. Moreover, numerous patients are open to an intermittent therapy. This trial aims to investigate whether two diet interventions can keep weight stable after weight loss with semaglutide in people with obesity or overweight.

NCT Number	NCT07711548
Lead Sponsor	Knut Mai Collaborators: University of Latvia, Institute for Clinical and Experimental Medicine, University of Vienna, ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK (ECRIN), Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DIfE), German Federal Ministry of Research, Technology, and Space (BMFTR), Austrian Science Fund (FWF), Czech Health Research Agency, Latvian Council of Science, Ministry of Health, Czech Republic, DLR Project Management Agency (DLR)
Conditions	Obesity & Overweight, Weight Loss Maintenance
Enrollment	292 participants
Start Date	2027-03
Primary Completion	2030-02 (estimated)
Study Completion	2030-04 (estimated)
Updated on ClinicalTrials.gov	2026-07-20