Effects of Hemoadsorption on Vascular Integrity in Septic Shock

This study aims to investigate the effects of adjunctive CytoSorb hemoadsorption therapy versus standard medical treatment on endothelial dysfunction in patients with refractory septic shock. The investigators hypothesize that hemoadsorption mitigates endothelial and glycocalyx injury by removing inflammatory mediators and other injurious circulating molecules, promoting hemodynamic stabilization.

NCT Number	NCT07711197
Lead Sponsor	Semmelweis University Collaborators: Ludwig Boltzmann Institute for Traumatology - The research center in cooperation with AUVA
Conditions	Septic Shock
Enrollment	110 participants
Start Date	2026-09-01
Primary Completion	2028-09-01 (estimated)
Study Completion	2029-01-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-17