Clinical Trial

Effects of Policosanol and Exercise on Fitness and Lipids in People With Elevated Blood Lipids

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Summary
This study will evaluate the effects of policosanol supplementation, concurrent exercise training, and their combination on physical fitness, muscle recovery, inflammatory markers, and blood lipid profiles in adults with elevated blood lipids who are not currently indicated for lipid-lowering medication. Participants will be randomly assigned to one of four groups for 12 weeks: policosanol plus exercise training, policosanol alone, placebo plus exercise training, or placebo without structured exercise training. Participants assigned to the supplementation groups will take policosanol 5 mg per day, while those assigned to the placebo groups will take a matching placebo. Participants assigned to the exercise groups will complete a standardized concurrent exercise training program combining aerobic and resistance exercise. The study will compare changes in physical fitness, lipid profiles, and selected blood biomarkers before and after the intervention. The findings may help determine whether low-dose policosanol, alone or combined with exercise training, can support cardiometabolic health and physical fitness in adults with dyslipidemia.
Trial Details
NCT Number NCT07710261
Lead Sponsor Mahidol University
Conditions Dyslipidemia, Elevated Blood Lipids, Physical Fitness, Exercise Training, Muscle Function, Handgrip Strength Test
Enrollment 120 participants
Start Date 2026-06-22
Primary Completion 2026-11-27 (estimated)
Study Completion 2027-01-29 (estimated)
Updated on ClinicalTrials.gov 2026-07-17