Clinical Trial

ENDOTRACHEAL Tube LIDOCAINE

Study acronym: ETT LIDOCAINE
Not Yet Recruiting Early Phase 1
View on ClinicalTrials.gov →
Summary
This prospective, randomized, double-blind, two-arm clinical trial will evaluate whether applying 5% lidocaine ointment to endotracheal tubes before intubation reduces airway irritation compared with standard water-based lubricant in adult patients undergoing general anesthesia. The primary objective is to determine whether lidocaine ointment decreases the incidence of coughing or bucking during emergence and extubation. Secondary objectives include evaluating the incidence and severity of postoperative sore throat and hoarseness, as well as intraoperative opioid requirements. Additional demographic and procedural data will be collected to characterize the study population and adjust for potential confounders. The study hypothesis is that 5% lidocaine ointment will reduce emergence coughing and improve postoperative airway comfort without increasing adverse outcomes.
Trial Details
NCT Number NCT07709390
Lead Sponsor Ohio State University
Conditions Emergency Coughing
Enrollment 212 participants
Start Date 2026-06-26
Primary Completion 2029-01-31 (estimated)
Study Completion 2029-01-31 (estimated)
Updated on ClinicalTrials.gov 2026-07-16