An Open-Label PET/CT Imaging Study to Evaluate Brain Serotonin Transporter (SERT) Occupancy Following Single-Dose Administration of LG-0317 Tablets in Healthy Participants

The purpose of the study is to evaluate brain serotonin transporter (SERT) receptor occupancy (RO) following single oral doses of LG-0317 tablets in healthy male participants; and to explore the pharmacokinetic/pharmacodynamic (PK/PD) relationship between LG-0317 plasma concentrations and SERT occupancy..

NCT Number	NCT07708428
Lead Sponsor	LinGang Laboratory
Conditions	Healthy Volunteers (HV)
Enrollment	12 participants
Start Date	2026-07-24
Primary Completion	2026-09-30 (estimated)
Study Completion	2027-02-02 (estimated)
Updated on ClinicalTrials.gov	2026-07-16