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970-nm Diode Laser Versus Liquid Nitrogen Cryotherapy in Maxillary Labial Frenectomy

Study acronym: MLF-DL-KRYO
StatusNot Yet Recruiting
PhaseNot applicable
Started
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Record History

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  1. Start date: Jul 30, 2026 to Nov 1, 2026
    • Eligibility criteria expanded, about 15 words
    • Secondary endpoints: details revised at 5 of 9 entries
    • Publications: details revised at 3 of 3 entries
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This prospective, randomized, single-blind, assessor-blinded, parallel-group clinical trial aims to compare the effects of 970-nm diode laser and liquid nitrogen cryotherapy in patients requiring maxillary labial frenectomy. The primary objective is to compare the change in salivary cortisol levels from baseline to postoperative day 2 between the two treatment groups. Secondary objectives include comparison of postoperative pain, edema, interincisal mouth opening, analgesic consumption, operation duration, state anxiety, clinical wound healing, and adverse events. Eligible adult patients with an indication for maxillary labial frenectomy will be randomly assigned to receive either 970-nm diode laser frenectomy or liquid nitrogen cryotherapy. Salivary cortisol samples and clinical outcomes will be assessed during the early postoperative follow-up period.
Trial Details
NCT Number NCT07708389
Lead Sponsor Kutahya Health Sciences University
Conditions
(from sponsor)		 Maxillary Labial Frenulum Abnormality, Hypertrophic Maxillary Labial Frenulum
Related terms Postoperative Pain
Enrollment 40 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov