This systematic review aims to evaluate the prevalence of digital eye strain (DES) among individuals engaged in online learning and remote work, identify associated demographic, behavioral, environmental, and ocular risk factors, and summarize evidence regarding preventive and therapeutic management strategies. Electronic databases including PubMed/MEDLINE, Scopus, Web of Science, Embase, Cochrane Library, and Google Scholar were systematically searched for relevant studies published from January 2020 onward. Eligible studies included observational and interventional studies involving online learners or remote workers that reported the prevalence, risk factors, or management of DES. Two independent reviewers performed study selection, data extraction, and quality assessment. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Where appropriate, quantitative synthesis using a random-effects meta-analysis was planned; otherwise, findings were synthesized narratively. The review is intended to provide evidence-based recommendations for reducing the burden of digital eye strain in educational and occupational settings characterized by prolonged digital device use.