Study of Probiotic Adjunctive Therapy for Decolonization of Carbapenem-Resistant Enterobacterales

To evaluate the efficacy of probiotic preparations as adjunctive therapy for the decolonization of intestinal carbapenem-resistant organisms (CRO), in comparison with conventional antibiotic therapy alone, with the primary endpoints including: (1) the clearance rate of intestinal CRO, defined as negative culture for carbapenem-resistant organisms, and (2) the safety assessment of the treatment, through the documentation of adverse events and potential side effects.

NCT Number	NCT07707869
Lead Sponsor	Second Affiliated Hospital, School of Medicine, Zhejiang University
Conditions	Enterobacteriaceae Infections, Carrier State
Enrollment	20 participants
Start Date	2026-03-01
Primary Completion	2026-12-31 (estimated)
Study Completion	2027-03-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-16