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Internal Organ and Musculoskeletal Assessment in Hypothyroidism (HYPOMORPH)

Study acronym: HYPOMORPH
StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary endpoint removed 4 → 3 primary endpoints
See other at-risk trials from Andijan State Medical Institute

Record History

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  1. Primary endpoint(s) modifiedv2 Show 7 more changesShow less
    • Recruitment opened
    • Interventions modified
    • Start date changed from estimate of Aug 1, 2026 to Jun 1, 2026
    • Secondary endpoints: 4 to 8
    • Study description shortened, about 17 words
    • Site details revised
    • Eligibility criteria shortened, about 4 words
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
HYPOMORPH is a hospital-based observational cross-sectional study designed to comprehensively characterise internal-organ morphometry and musculoskeletal status in adults with previously diagnosed hypothyroidism receiving routine medical care in Andijan, Uzbekistan. Approximately 500 adults aged 18-59 years will be included. Participants undergo standardised clinical and anthropometric assessment, ultrasonographic examination of the liver, pancreas and both kidneys, measurement of handgrip strength, and assessment of physical performance using the Five Times Sit-to-Stand Test and 4-m gait speed test. Sarcopenia risk and habitual physical activity are assessed using the SARC-F questionnaire and the International Physical Activity Questionnaire-Short Form (IPAQ-SF), respectively. Serum thyroid-stimulating hormone (TSH) and free thyroxine (FT4) concentrations are measured to characterise thyroid functional status at the time of assessment. The study evaluates ultrasonographic morphometric characteristics of the liver, pancreas and kidneys and musculoskeletal functional characteristics, and investigates their associations with thyroid-related, anthropometric, clinical and laboratory variables. Multivariable regression analyses will be used to identify factors independently associated with organ-specific morphometric and functional outcomes.
Trial Details
NCT Number NCT07707830
Lead Sponsor Andijan State Medical Institute
Conditions
(from sponsor)		 Hypothyroidism
Related terms Hypothyroidism, Motor Activity, Sarcopenia
Enrollment 500 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov