Clinical Trial

Tirzepatide's Effects on Epigenetic Aging and Metabolic Restoration in Virally Suppressed People With HIV

Enrolling by Invitation Phase 4
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Summary
This study is a pilot, open-lable, two-arm study. The investigators will enroll virally suppressed people living with HIV and obesity to evaluate the effect of tirzepatide on epigenetic aging, assessed by DNA methylation-based clocks using peripheral blood. In parallel, imaging studies will be performed to assess changes in body composition and intrahepatic fat content.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2026-07-12.
Trial Details
NCT Number NCT07707778
Lead Sponsor National Taiwan University Clinical Trial Center
Conditions Human Immunodeficiency Virus (HIV), Metabolic Dysfunction Associated Steatotic Liver Disease, Dyslipidaemia, Diabetes Mellitus, Obesity & Overweight, Metabolic Syndrome
Enrollment 60 participants
Start Date 2026-06-25
Primary Completion 2027-12 (estimated)
Study Completion 2027-12 (estimated)
Updated on ClinicalTrials.gov 2026-07-20