Heart Rate Variability and Medication Adherence in Resistant Hypertension

This single-center, cross-sectional observational study examines the relationship between adherence to antihypertensive therapy - verified objectively by therapeutic drug monitoring (TDM) - and heart rate variability (HRV) in patients with resistant hypertension. Patients are recruited opportunistically, in a nurse-led manner, in a one-day-care cardiology unit, and undergo a single examination: a short-term HRV recording (Polar H10), a single blood draw for antihypertensive drug levels, office blood pressure, and self-completed questionnaires. There is no follow-up.

NCT Number	NCT07707583
Lead Sponsor	Nemocnice AGEL Trinec-Podlesi a.s. Collaborators: Masaryk University
Conditions	Resistant Hypertension, Medication Adherence, Autonomic Nervous System
Enrollment	150 participants
Start Date	2026-07-20
Primary Completion	2027-07-20 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-16