Cardiovascular Effects of Parathyroid Hormone Analogues in Chronic Hypoparathyroidism

The goal of this study is to evaluate cardiovascular effects of long-acting parathyroid hormone (PTH) analogues in adults with chronic hypoparathyroidism. The main questions it aims to answer are: * Do patients with hypoparathyroidism have increased arterial stiffness and markers of subclinical cardiovascular injury compared to healthy individuals? * Does treatment with a long-acting PTH analogue improve vascular and cardiac function over time compared to conventional therapy? This is a multi-center study with two parts: a cross-sectional comparison and a 12-month prospective follow-up. Adults with chronic hypoparathyroidism and matched healthy controls will undergo clinical evaluation, vascular measurements, cardiac imaging, and blood tests. In the prospective part, patients that just started long-acting PTH analogue therapy based on their treating physicians choice will be followed for 12 months, with repeat assessments at baseline, 3 months, and 12 months to evaluate changes in cardiovascular markers.

NCT Number	NCT07707479
Lead Sponsor	National and Kapodistrian University of Athens Collaborators: 251 Hellenic Air Force & VA General Hospital, Alexandra Hospital, Athens, Greece, G.Gennimatas General Hospital, Laikο General Hospital, Athens, Korgialenio-Benakio Red Cross Hospital, AHEPA University Hospital, 424 General Military Hospital, Hippocration General Hospital, KAT General Hospital, Evaggelismos Hospital, Greece
Conditions	Chronic Hypoparathyroidism
Enrollment	210 participants
Start Date	2026-04-01
Primary Completion	2027-04-01 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-16