Remimazolam Combined With Oliceridine for Sedation in Elderly Patients Undergoing Gastrointestinal Endoscopy

This study aims to evaluate the sedative efficacy and safety of remimazolam combined with oliceridine in elderly patients undergoing painless gastrointestinal endoscopy. Elderly patients often face higher risks of respiratory and hemodynamic depression during clinical sedation. This trial will investigate whether the combination of remimazolam and oliceridine can provide stable sedation, maintain stable vital signs, and reduce the incidence of adverse events such as hypoxemia and postoperative cognitive fluctuation in this vulnerable population.

NCT Number	NCT07707258
Lead Sponsor	Baoshan Branch, Renji Hospital, Shanghai Jiao Tong University School of Medicine
Conditions	Sedation, Gastrointestinal Endoscopy
Enrollment	240 participants
Start Date	2026-07-17
Primary Completion	2026-09-01 (estimated)
Study Completion	2026-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-21