Working Mechanisms and Effectiveness of IV Ketamine-assisted Psychotherapy on Depression in TRD Clients

Ketamine-Assisted Psychotherapy (KAP) is an innovative treatment that combines intravenous ketamine with psychotherapy in a carefully monitored clinical setting. At Senz, this treatment is being evaluated in an open-label clinical trial for individuals with persistent depression who have not responded sufficiently to previous treatments. The combination of ketamine, psychological support, and integration sessions aims to promote emotional processing, psychological flexibility, and lasting therapeutic change.

NCT Number	NCT07706478
Lead Sponsor	Senz Collaborators: Radboud University Medical Center
Conditions	Treatment Resistant Depression
Enrollment	120 participants
Start Date	2025-06-01
Primary Completion	2033-01 (estimated)
Study Completion	2033-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-15