DBC-664 in Adult Patients With Solid Tumors

DBC-664-ONC-101 is a first-in-human Phase 1a/1b open-label, multicenter study to evaluate the safety, tolerability, PK, pharmacodynamic, and preliminary anti-tumor activity of DBC-664 in patients with endometrial cancer, ovarian cancer, and other advanced solid tumors . This study is divided into 2 parts: Phase-1a Dose Escalation (Part 1), and Phase-1b Dose Expansion (Part 2). In each part, patients who meet specific eligibility criteria will be enrolled.

NCT Number	NCT07705035
Lead Sponsor	Duboce Biopharmaceuticals, Inc.
Conditions	Malignant Germ Cell Tumor, Lung Adenocarcinoma, Gastric/Esophageal/Gastroesophageal Junction (GEJ) Adenocarcinoma, Urothelial Carcinoma, Endometrial Adenocarcinoma, Ovarian Adenocarcinoma
Enrollment	210 participants
Start Date	2026-06-17
Primary Completion	2030-04-01 (estimated)
Study Completion	2030-04-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-23