Assessing Covert Consciousness During Dexmedetomidine and Ketamine Sedation: An fMRI Study

This research is studying whether mental functions take place during different levels of anesthesia, using a commonly used drug (either dexmedetomidine \[with propofol in some participants\] or ketamine), which shows areas in the brain involved in thinking at different depths of anesthesia. As a result of this study, the researchers expect to gain a deeper understanding of mental function during different levels of anesthesia.

NCT Number	NCT07705022
Lead Sponsor	University of Michigan Collaborators: National Institute of General Medical Sciences (NIGMS)
Conditions	Healthy, Covert Consciousness
Enrollment	60 participants
Start Date	2026-08-07
Primary Completion	2028-01 (estimated)
Study Completion	2028-01 (estimated)
Updated on ClinicalTrials.gov	2026-08-11