A Randomized Controlled Trial of Doxycycline Post Exposure Prophylaxis to Prevent Incident Bacterial STIs Among Women in the United States

The bacterial sexually transmitted infections (STIs) chlamydia, gonorrhea, and syphilis cause multiple adverse outcomes in women, and prevention strategies are critically needed. This project will determine the efficacy of doxycycline post-exposure prophylaxis (doxy PEP) to prevent STIs among women through a phase IV, open-label, randomized controlled trial.

NCT Number	NCT07704957
Lead Sponsor	Tulane University Collaborators: National Institute of Allergy and Infectious Diseases (NIAID), University of Alabama at Birmingham, Louisiana State University Health Sciences Center in New Orleans
Conditions	Chlamydia Females, Gonorrhea Female, Syphilis Female, Adherence, Prophylaxis, Prevention
Enrollment	519 participants
Start Date	2027-01-01
Primary Completion	2031-02-28 (estimated)
Study Completion	2032-04-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-15