This randomized controlled experimental study was conducted to evaluate the effects of virtual reality glasses used during hemodialysis on patients' vital signs and anxiety levels. A total of 56 adult patients receiving hemodialysis at Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital were randomly assigned to either an experimental group or a control group. Patients in the experimental group watched a 4K virtual reality nature video with relaxing background music during hemodialysis, while the control group received standard hemodialysis care. Vital signs, pain, anxiety, and satisfaction were assessed to evaluate the effectiveness of the virtual reality intervention.