ABCG8, UGT1A1 and Gallstone Disease After Bariatric Surgery

The goal of this observational genetic case-control study is to learn whether two specific genetic variants in ABCG8 and UGT1A1 are associated with gallstone disease after bariatric surgery. The study includes adults who have previously undergone bariatric surgery. The main questions it aims to answer are whether the ABCG8 D19H variant and the UGT1A1 rs6742078 variant are associated with an increased risk of gallstone disease requiring cholecystectomy after bariatric surgery. Researchers will compare patients who underwent bariatric surgery and later had their gallbladder removed because of gallstone disease with patients who underwent bariatric surgery but did not develop gallstone disease or undergo cholecystectomy during follow-up. Participants will provide one blood sample for targeted genetic analysis and complete questionnaires about health, previous surgery, medication use, family history, and gastrointestinal quality of life. Relevant clinical information will also be collected from medical records.

NCT Number	NCT07702630
Lead Sponsor	Esbjerg Hospital - University Hospital of Southern Denmark Collaborators: Odense University Hospital, University of Southern Denmark
Conditions	Gallstone Disease, Bariatric Surgery, Metabolic Surgery, Cholecystectomy, Genetics
Enrollment	270 participants
Start Date	2026-10-01
Primary Completion	2029-01-01 (estimated)
Study Completion	2029-03-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-17