Placental Progesterone Membrane Receptors in Fetal Growth Restriction

This prospective observational case-control study aims to compare placental expression levels of progesterone membrane receptors, including PGRMC1, PGRMC2, and PAQR family receptors, among pregnancies affected by impaired fetal growth and appropriately grown control pregnancies. Pregnancies with suspected impaired fetal growth were phenotypically classified before biomarker analyses according to the contemporary Delphi consensus and ISUOG diagnostic criteria into fetal growth restriction (FGR) and small for gestational age (SGA). Placental tissue samples obtained at delivery were analyzed using quantitative real-time polymerase chain reaction (qRT-PCR). The final study cohort comprised 110 singleton pregnancies, including 48 FGR, 29 SGA, and 33 appropriately grown controls. The study also evaluated the association between progesterone membrane receptor expression and adverse perinatal outcomes.

NCT Number	NCT07701837
Lead Sponsor	Samsun University
Conditions	Fetal Growth Restriction, Placenta, Progesterone Membrane Receptor, PGRMC1, PGRMC2, Placental Dysfunction, Pregnancy
Enrollment	110 participants
Start Date	2025-08-01
Primary Completion	2026-07-20 (estimated)
Study Completion	2026-07-20 (estimated)
Updated on ClinicalTrials.gov	2026-08-07