Prognostic Impact of Coronary Microvascular Dysfunction After IVL Versus RA in Patients With Severe Coronary Calcification Undergoing PCI

The goal of this observational study is to lean that whether the distinct mechanisms by which intravascular lithotripsy (IVL) and rotational atherectomy (RA) treat severe coronary calcification differentially affect the microcirculation, leading to coronary microvascular dysfunction (CMD). The main question it aims to answer is: we evaluated the prognostic value of post-percutaneous coronary intervention (PCI) CMD, assessed by the angiography-derived index of microcirculatory resistance (angio-IMR), in patients with severe coronary calcification undergoing RA or IVL. Participants will answer survey questions about their clinical outcomes for 1 year by telephone

NCT Number	NCT07699965
Lead Sponsor	Second Affiliated Hospital, School of Medicine, Zhejiang University
Conditions	Coronary Artery Calcification, Intravascular Lithotripsy, Coronary Microcirculation Dysfunction
Enrollment	590 participants
Start Date	2018-01-01
Primary Completion	2024-12-31 (estimated)
Study Completion	2026-09-30 (estimated)
Updated on ClinicalTrials.gov	2026-07-13