Anti-inflammatory Effects of Curcumin, Ginger and Piperine Supplementation in Ultra-trail Runners: a Double-blind Randomized Placebo-controlled Trial

ECUM-RUN is a randomized, double-blind, placebo-controlled phase 3 trial evaluating whether a 30-day oral supplementation with curcumin, ginger, and piperine (9-5-1 formulation) reduces exercise-induced joint pain and inflammatory markers in 82 ultra-trail runners competing in the Diagonale des Fous (175 km). The primary endpoint is the change in knee pain (VAS score) between end of supplementation and race finish, compared between intervention and placebo groups.

NCT Number	NCT07699575
Lead Sponsor	Centre Hospitalier Universitaire de la Réunion
Conditions	Joint Pains
Enrollment	100 participants
Start Date	2026-09-14
Primary Completion	2026-10-20 (estimated)
Study Completion	2026-10-20 (estimated)
Updated on ClinicalTrials.gov	2026-07-13