Clinical Trial

Cyanoacrylate Glue Versus Absorbable Gelatin Sponge for Gastric Varices

Study acronym: CoAGS-GV
Not Yet Recruiting
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Summary
This study compares two endoscopic ultrasound-guided treatments for gastric varices, which are enlarged veins in the stomach that can bleed. Both treatments use small coils placed into the varix. One group will receive coils with cyanoacrylate medical glue, and the other group will receive coils with absorbable gelatin sponge. The purpose of the study is to determine whether absorbable gelatin sponge with coils is not worse than cyanoacrylate glue with coils for closing off gastric varices, and to compare safety outcomes. Participants will be randomly assigned to one of the two treatment groups. Participants and outcome assessors will not know which treatment was used, but the doctor performing the procedure will know. After the procedure, participants will be followed for up to 12 months. Follow-up may include clinical assessments, questionnaires about health and quality of life, CT imaging shortly after the procedure, and repeat endoscopic ultrasound assessments to evaluate whether the gastric varix has been successfully treated.
Trial Details
NCT Number NCT07699354
Lead Sponsor Unity Health Toronto
Collaborators: University of Toronto
Conditions Gastric Varices Bleeding, Gastric Varices, Portal Hypertension
Enrollment 64 participants
Start Date 2026-08-01
Primary Completion 2027-11-01 (estimated)
Study Completion 2029-08-01 (estimated)
Updated on ClinicalTrials.gov 2026-07-13