Clinical Trial

Effect of Controlled Hypotension on GFAP and Cognition in Rhinoplasty

Not Yet Recruiting
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Summary
This prospective observational study aims to evaluate the neurological safety of controlled hypotension (Mean Arterial Pressure 50-65 mmHg) during elective rhinoplasty. The investigators will assess whether this standard intraoperative hypotensive strategy causes cellular stress by measuring serum Glial Fibrillary Acidic Protein (GFAP) levels and early postoperative cognitive changes using the Montreal Cognitive Assessment (MoCA) test.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2026-07-07.
Trial Details
NCT Number NCT07699133
Lead Sponsor Kahramanmaras Sutcu Imam University
Conditions Nasal Septum Deviation, Rhinoplasty, Induced Hypotension
Enrollment 40 participants
Start Date 2026-07-10
Primary Completion 2027-02-28 (estimated)
Study Completion 2027-03-30 (estimated)
Updated on ClinicalTrials.gov 2026-07-14