The Safety and Microbial Changes in the Use of Intranasal Neosporin®

Neosporin is an over-the-counter, FDA-approved triple-antibiotic ointment. It is widely used to treat and prevent skin infections following minor burns and injuries. Although the Neosporin® prospect indicates its use is strictly topical, it is often used intranasally by ear, nose, and throat specialists, plastic surgeons, and intensivists to prevent and treat various conditions. Nonetheless, no literature has documented the safety of intranasal Neosporin®. We designed a prospective study to assess the safety of this intervention in healthy participants and to investigate microbial changes before and after the intervention. Healthy participants will apply Neosporin® intranasally for 15 days and record daily adverse events and their severity. Nasal cultures will be drawn before and after the intervention and compared.

NCT Number	NCT07698938
Lead Sponsor	Hospital Universitario Dr. Jose E. Gonzalez
Conditions	Teste the Safety of (Polymyxin B Sulfate 500,000 IU, Bacitracin Zinc 40,000 IU, Neomycin Sulfate 0.35g Neomycin Base) Intranasally
Enrollment	12 participants
Start Date	2025-02-13
Primary Completion	2025-03-22 (estimated)
Study Completion	2025-03-23 (estimated)
Updated on ClinicalTrials.gov	2026-07-14