Clinical Trial

Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use

Recruiting
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Summary
Oral nicotine pouches (ONPs) are non-combustible nicotine products that may reduce cigarette craving and smoking cue-induced brain activity, supporting their potential as harm-reduction tools for adults who smoke cigarettes. This within-subject, repeated-measures study will evaluate the acute effects of a single 6 mg oral nicotine pouch on subjective craving and prefrontal neural responses to smoking-related cues using functional near-infrared spectroscopy (fNIRS). Participants will complete assessments before and after nicotine pouch administration following overnight nicotine abstinence to characterize changes in craving and neural cue reactivity.
Trial Details
NCT Number NCT07698470
Lead Sponsor University of Southern California
Conditions Nicotine Dependence
Enrollment 45 participants
Start Date 2026-04-30
Primary Completion 2027-07 (estimated)
Study Completion 2027-08 (estimated)
Updated on ClinicalTrials.gov 2026-07-13