Clinical Trial

End-Expiratory Diaphragmatic Residual Contraction Index for Identifying Intrinsic PEEP and Assisting PEEP Titration: A Prospective Physiological Study

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Summary
This study proposes the End-expiratory Diaphragmatic Residual Contraction (EDRC) index to quantify residual diaphragmatic activity at end-expiration during Pressure Support Ventilation (PSV) mode. The study aims to validate the relationship between EDRC and dynamic intrinsic PEEP (PEEPi), triggering load, patient-ventilator asynchrony, and PEEP responsiveness through a brief, standardized PEEP titration trial conducted within a clinically safe range. This will provide a basis for subsequent individualized PEEP setting guided by EDRC.
Trial Details
NCT Number NCT07697703
Lead Sponsor Sir Run Run Shaw Hospital
Conditions Speckle Tracking, Diaphragm
Enrollment 100 participants
Start Date 2026-08-21
Primary Completion 2027-08-24 (estimated)
Study Completion 2027-09-03 (estimated)
Updated on ClinicalTrials.gov 2026-07-13