Clinical Trial

Adjunctive Antioxidant Effect of Centella Asiatica Nanoemulsion Gel in Management of Periodontitis

Completed
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Summary
The aims of the current study are: 1. Evaluation of the clinical efficacy of local delivery of nanoemulsion gel containing Centella asiatica extract as an adjunct to conventional non-surgical periodontal therapy in periodontitis patients. 2. Evaluation of the antioxidant effect of this treatment by the assessment of nuclear factor erythroid 2-related factor 2 (NrF2) and glutathione peroxidase 1 (GPX1) in the gingival crevicular fluid (GCF) samples.
Trial Details
NCT Number NCT07697209
Lead Sponsor Mansoura University
Conditions Periodontal Diseases, Periodontal Bone Loss
Enrollment 45 participants
Start Date 2025-03-21
Primary Completion 2025-09-08 (estimated)
Study Completion 2025-09-08 (estimated)
Updated on ClinicalTrials.gov 2026-07-13