Clinical Outcomes and Host Immune Response in Vascular Graft and Endograft Infections

ACHIEVE is a prospective observational cohort and biobank study of patients with suspected or diagnosed central vascular graft or endograft infection. The study also includes patients undergoing elective central vascular graft or endograft implantation and healthy blood donor controls. Participants undergo longitudinal clinical data collection and biospecimen sampling. The study aims to characterize clinical outcomes, host immune responses, inflammatory biomarkers, pathogen-related factors, and novel microbiological diagnostic methods, including microbial cell-free DNA sequencing, in vascular graft and endograft infections.

NCT Number	NCT07696884
Lead Sponsor	Aarhus University Hospital Collaborators: Aalborg University, Central Denmark Region, Randers Regional Hospital, Gødstrup Hospital, Regionshospitalet Horsens, University of Aarhus, Viborg Regional Hospital
Conditions	Vascular Graft Infection, Vascular Endograft Infection, Aortic Graft Infection
Enrollment	300 participants
Start Date	2024-05-17
Primary Completion	2033-09-01 (estimated)
Study Completion	2033-09-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-10