C-PRF With Minimally Invasive Non-Surgical Periodontal Therapy

This randomized controlled clinical study evaluated whether concentrated platelet-rich fibrin (C-PRF) provides additional clinical and radiographic benefits when used together with minimally invasive non-surgical periodontal treatment (MINST) in patients with advanced periodontitis and intrabony periodontal defects. Thirty systemically healthy patients with stage III-IV periodontitis were included. Each participant had at least one intrabony defect with a probing pocket depth of 6 mm or greater and a radiographic intrabony component of 3 mm or greater. Participants were randomly assigned to receive either MINST alone or MINST combined with C-PRF application. Clinical periodontal measurements, including probing pocket depth, clinical attachment level, plaque score, bleeding on probing, and gingival recession, were recorded at baseline and at the 6-month follow-up. Standardized periapical radiographs were used to evaluate radiographic outcomes, including total defect depth, intrabony defect depth, defect angle, and linear bone fill.

NCT Number	NCT07696845
Lead Sponsor	Altinbas University
Conditions	Periodontitis, Intrabony Periodontal Defect, Non Surgical Periodontal Treatment
Enrollment	30 participants
Start Date	2025-07-10
Primary Completion	2027-02-09 (estimated)
Study Completion	2027-02-09 (estimated)
Updated on ClinicalTrials.gov	2026-08-07