Randomized Trial of Percutaneous vs. Endoscopic Gallbladder Drainage

This is a randomized trial of patients with acute calculous cholecystitis who are never-surgery candidates. Patients will be randomized to one of two treatment groups, percutaneous cholecystostomy or endoscopic ultrasound-guided drainage. The aim of the study is to compare between these two treatment methods, the treatment outcomes and quality of life over a follow-up duration of 36 months.

NCT Number	NCT07696546
Lead Sponsor	Orlando Health, Inc.
Conditions	Acute Cholecystitis
Enrollment	110 participants
Start Date	2026-07
Primary Completion	2032-06 (estimated)
Study Completion	2032-12 (estimated)
Updated on ClinicalTrials.gov	2026-07-10