Hippo-YAP Pathway and Related miRNAs in Preterm Birth

This completed observational study evaluated the expression of Hippo-YAP pathway-related genes and proteins and selected microRNAs in maternal blood, placental tissue, and myometrial tissue obtained from women who underwent cesarean delivery at term or preterm gestational ages. The study compared women with spontaneous preterm delivery and women with term delivery. Maternal blood, placental tissue, and myometrial tissue samples were analyzed using molecular, biochemical, and immunohistochemical methods to explore whether Hippo-YAP pathway activity and related miRNA expression patterns may be associated with the pathophysiology of preterm birth.

NCT Number	NCT07695467
Lead Sponsor	Cumhuriyet University Collaborators: The Scientific and Technological Research Council of Turkey
Conditions	Preterm Birth, Pregnancy, Preterm Labor
Enrollment	44 participants
Start Date	2021-06-01
Primary Completion	2024-04-01 (estimated)
Study Completion	2024-05-31 (estimated)
Updated on ClinicalTrials.gov	2026-07-10