Clinical Trial

"Is Antibiotic Therapy Necessary for Patients Undergoing Extraction of Teeth With Abscess?"

Completed
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Summary
This is a triple-blind randomized controlled trial conducted at the Department of Oral and Maxillofacial Surgery, Subbaiah Institute of Dental Sciences, Shimoga. The study enrolls 176 adult patients aged above 18 years belonging to ASA class 1 or 2, requiring intra-alveolar extraction of non-restorable carious teeth with radiographic evidence of periapical abscess of less than 1.5 cm in diameter. Patients are randomly allocated into two equal groups of 88 each. Group A receives postoperative Amoxicillin 500 mg thrice daily for 5 days in addition to standard analgesics. Group B receives only standard analgesics with no antibiotic prescription. The primary outcome measure is wound healing assessed on postoperative day 5 using a modified Landry Wound Healing Index evaluating gingival tissue color, response to palpation, presence of granulation tissue, and suppuration.
Trial Details
NCT Number NCT07694531
Lead Sponsor Subbaiah Institute of Dental Sciences
Conditions Periapical Abscess
Enrollment 176 participants
Start Date 2025-03-20
Primary Completion 2025-09-05 (estimated)
Study Completion 2025-09-10 (estimated)
Updated on ClinicalTrials.gov 2026-07-10