Clinical Trial

Efficacy of 1% Nanochitosan Solution in the Treatment of Denture Stomatitis

Completed Phase 2
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Summary
The purpose of this study is to evaluate and compare the clinical efficacy of a 1% nanochitosan solution versus a standard Nystatin oral suspension in patients diagnosed with Newton's type II denture stomatitis (chronic atrophic candidiasis). Chitosan nanoparticles are investigated as a potential biocompatible, mucoadhesive alternative to traditional antifungal treatments to accelerate mucosal healing and reduce the erythema of the palatal mucosa.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2026-07-03.
Trial Details
NCT Number NCT07694024
Lead Sponsor Kerman University of Medical Sciences
Conditions Denture Stomatitis, Chronic Atrophic Candidiasis
Enrollment 30 participants
Start Date 2016-01-17
Primary Completion 2016-05-04 (estimated)
Study Completion 2016-05-04 (estimated)
Updated on ClinicalTrials.gov 2026-07-13