Senescence in Myocardial Infarction

The investigators of this study have found that after a heart attack, some heart cells rapidly age (become senescent) and release proteins that make the heart disease worse. The investigators of this study would like to check for these aged-cell proteins in participants who have coronary artery bypass graft (CABG) surgery after a recent heart attack or to treat more stable heart disease. The investigators will do this by taking blood samples and a sample of normally discarded heart tissue from each group of participants. This might help tell us who is at the highest risk of developing heart disease and how people recover from a heart attack.

NCT Number	NCT07693712
Lead Sponsor	South Tees Hospitals NHS Foundation Trust Collaborators: Newcastle University
Conditions	Cardiovascular Diseases, Coronary Artery Disease, Aging, Atherosclerosis, Myocardial Infarction, Inflammation, Heart Failure
Enrollment	22 participants
Start Date	2024-05-08
Primary Completion	2026-02-26 (estimated)
Study Completion	2026-02-26 (estimated)
Updated on ClinicalTrials.gov	2026-07-09