Clinical Trial

Topical Herbal Medicine for Chemotherapy-Induced Peripheral Neuropathy

Active, Not Recruiting Phase 2
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Summary
The goal of this clinical trial is to learn if menthol works to relieve chronic neuropathic pain and chemotherapy-induced peripheral neuropathy (CIPN). The primary objectives are to evaluate the safety and clinical efficacy of menthol-containing gloves and foot-covers, specifically whether they can improve patient-reported hypoesthesia (numbness). Secondary objectives include assessing the sustained effects on pain, dysesthesia (abnormal sensations), allodynia (touch-induced pain), and overall quality of life. Additionally, this study will include an exploratory lab analysis using blood samples to investigate potential biological markers (small extracellular vesicles and microRNA) associated with treatment responses. Participants will be asked to: Wear menthol-containing gloves and foot-covers (or shams) daily for 5 minutes per session over a 14-day period. Attend clinic visits on Days 1, 14, 21, and 28 for evaluations and tests.
Trial Details
NCT Number NCT07693387
Lead Sponsor Taiwan Municipal An-Nan Hospital-China Medical University
Collaborators: China Medical University, Taiwan
Conditions Chemotherapy-induced Peripheral Neuropathy (CIPN)
Enrollment 40 participants
Start Date 2025-05-12
Primary Completion 2027-01-31 (estimated)
Study Completion 2027-01-31 (estimated)
Updated on ClinicalTrials.gov 2026-07-09