Multimodal Evaluation-Guided Surveillance-Intervention With Endoscopic Selective Neck Dissection for Post-Radiotherapy N3 Nasopharyngeal Carcinoma

This randomized trial evaluates a multimodal surveillance strategy in nasopharyngeal carcinoma patients with high-risk N3 cervical lymph node involvement after radiotherapy. Patients are assigned to standard follow-up or an enhanced strategy using CEUS, imaging, and EBV DNA for risk assessment. The intervention group uses multimodal evaluation to identify high-risk patients who may undergo multidisciplinary review and selective neck dissection when indicated. The primary endpoint is failure-free survival (FFS). Secondary endpoints include OS, LRRFS, DMFS, and safety .

NCT Number	NCT07692906
Lead Sponsor	Xuelei Ma MD Collaborators: West China Hospital of Stomatology, Sichuan Cancer Hospital and Research Institute, General Hospital of Western Theater Command, PLA, Yibin Second People's Hospital, Miyi County People's Hospital, Jintang First People's Hospital, Yilong County people's Hospital
Conditions	Nasopharyngeal Cancinoma (NPC)
Enrollment	80 participants
Start Date	2026-08-01
Primary Completion	2035-06-30 (estimated)
Study Completion	2035-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-07-09