TG-INSIGHT With Joint POCUS, Hemostatic Potential in Patients With Severe Hemophilia A on Novel Replacement and Substitution FVIII Therapies

This is an observational research study to find out if there is a difference in the way children with moderate or severe hemophilia A, treated on two different types of factor replacement, form a clot and also evaluate if they develop tiny bleeds within the joint and subsequently early joint changes when receiving extended half-life factor VIII.

NCT Number	NCT07692217
Lead Sponsor	University of Texas Southwestern Medical Center Collaborators: Sanofi
Conditions	Hemophilia A, Factor VIII (FVIII)
Enrollment	60 participants
Start Date	2026-07
Primary Completion	2033-05 (estimated)
Study Completion	2033-05 (estimated)
Updated on ClinicalTrials.gov	2026-07-09