Clinical Trial

Intra-Articular PRP Versus Dexamethasone for TMJ Internal Derangement

Completed
View on ClinicalTrials.gov →
Summary
This study looked at whether an injection into the jaw joint (temporomandibular joint, or TMJ) can help people who have pain, clicking, and difficulty opening their mouth due to a slipped joint disc. Thirty patients were randomly assigned to receive one of three injections: platelet-rich plasma (PRP, made from the patient's own blood), a steroid medication (dexamethasone) with a local anesthetic, or a saline (salt water) injection as a comparison. Pain, joint clicking, and mouth opening were measured before the injection and one week later. The study found that both PRP and the steroid injection reduced pain and clicking more than saline, and PRP also improved how wide patients could open their mouth.
Trial Details
NCT Number NCT07691684
Lead Sponsor University Of Anbar
Conditions Temporomandibular Joint Disorders, Temporomandibular Joint Internal Derangement, Temporomandibular Joint Dysfunction Syndrome
Enrollment 30 participants
Start Date 2025-12-10
Primary Completion 2026-04-09 (estimated)
Study Completion 2026-04-09 (estimated)
Updated on ClinicalTrials.gov 2026-07-09