Clinical Trial

Osteoporotic Fracture and Lidocaine Plaster 5% for Neuropathic Pain preventioN

Study acronym: FLYNN
Not Yet Recruiting Phase 4
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Summary
Osteoporotic vertebral fractures may lead to chronic pain with a neuropathic component, which is often underdiagnosed and undertreated in older adults. This proof-of-concept randomized controlled trial aims to evaluate whether early application of a 5% lidocaine plaster can prevent the development of neuropathic pain following an osteoporotic vertebral fracture. Participants will be randomized in a 2:1 ratio to receive either a daily 5% lidocaine plaster plus standard care or standard care alone for 2 months. The primary outcome is the proportion of participants who develop neuropathic pain at 2 months, assessed using the PainDETECT questionnaire.
Trial Details
NCT Number NCT07691359
Lead Sponsor University Hospital, Clermont-Ferrand
Conditions Osteoporotic Vertebral Fracture, Neuropathic Pain
Enrollment 30 participants
Start Date 2026-07-01
Primary Completion 2027-10-01 (estimated)
Study Completion 2028-10-01 (estimated)
Updated on ClinicalTrials.gov 2026-07-08